What is MOTS-C?
MOTS-C is a 16-amino acid mitochondrial-derived peptide encoded by the 12S rRNA region of mitochondrial DNA. This groundbreaking peptide represents a new paradigm in mitochondrial-nuclear communication, promoting metabolic homeostasis, longevity, and exercise performance through AMPK pathway activation.
Mitochondrial Origin
MOTS-C is encoded by mitochondrial DNA and represents a unique retrograde signaling mechanism from mitochondria to the nucleus.
AMPK Activation
MOTS-C regulates the folate cycle and activates AMPK through AICAR, promoting cellular energy homeostasis and stress adaptation.
Research and Potential Benefits
MOTS-c's most prominent benefit is significant weight loss, as demonstrated in the landmark STEP clinical trials.
- ✓ Reduces Appetite: It acts on brain centers to reduce hunger and increase feelings of fullness.
- ✓ Slows Digestion: It slows how quickly the stomach empties, helping you feel full for longer.
- ✓ Clinically Proven: Studies have shown average weight loss of 15-20% of body weight in individuals with obesity.
Originally developed for type 2 diabetes, MOTS-c is highly effective at managing blood glucose levels.
- ✓ Stimulates Insulin: It prompts the pancreas to release insulin when blood sugar is high.
- ✓ Suppresses Glucagon: It reduces the release of glucagon, a hormone that raises blood sugar.
As an FDA-approved medication, MOTS-c has a well-documented safety profile but must be used under medical supervision.
- ! Prescription Required: It is not a supplement and requires a prescription from a licensed healthcare provider.
- ! Common Side Effects: Gastrointestinal issues like nausea, vomiting, and diarrhea are common, especially when starting.
- ! Contraindications: Not suitable for people with a personal or family history of medullary thyroid carcinoma or MEN 2.
References & Citations
Ask Dr. John About MOTS-c
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